Product Details
Alternative Name: | TNF receptor-associated factor 6 |
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Host: | Rabbit |
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Immunogen: | Recombinant mouse TRAF6 (N-terminal fragment). |
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UniProt ID: | P70196 |
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Species reactivity: | Mouse
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Applications: | IP, WB
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Recommended Dilutions/Conditions: | Immunoprecipitation (2-4µL/100-500 µl cell extract from 5x106 cells)
Western Blot (1:1000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~58kDa by Western blot. |
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Purity Detail: | Immunoaffinity purified. |
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Formulation: | Liquid. In PBS containing 50% glycerol. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | TRAF proteins are multifunctional signal adaptors that are involved in the activation of the kinase cascades which activate c-Jun N-terminal kinase, p38 mitogen activated protein kinase, and the transcription factor NF-κB. Members of the TRAF family form homodimers as well as heterodimers, resulting in extensive diversity and specificity to their function in signal transduction pathways. |
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Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of L5178Y (1), WR19L (2) and NIH/3T3 (3) cells, probed with TRAF6 pAb.
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Product Literature References
A high-throughput pipeline for validation of antibodies: K. Sikorski, et al.; Nat. Methods
15, 909 (2018),
Abstract;
The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis: T. Izawa, et al.; J. Immunol.
197, 4639 (2016),
Abstract;
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