| ADI-AAM-072-E | 100 µg | 402.00 USD |  |
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| Clone: | 83-8B |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant rat Bcl-2 β. |
| UniProt ID: | P49950 |
| Gene/Protein Identifier: | NP_058689 (RefSeq) |
| Species reactivity: | Human, Mouse, Rat Drosophila |
| Applications: | Flow Cytometry, WB |
| Recommended Dilutions/Conditions: | Flow Cytometry (10µg/ml) Western Blot (1µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~26kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The Bcl-2 family of proteins regulate the intrinsic apoptotic pathway and are characterized by the sharing of at least one of four conserved Bcl-2 Homology (BH) domains. Bcl-2 family members function as either pro- or anti-apoptotic factors, and are generally categorized into three groups based on structural homology and function. Bcl-2-like proteins (Bcl-2, Bcl-xL, Bcl-w, A1, and Mcl-1) are pro-survival. Pro-apoptotic members can be sub-divided into two groups: the multi-BH domain group, including Bax, Bak, and Bok; and the more numerous and diverse BH3-only group, which includes Bim, Bad, and Bid. |
| Regulatory Status: | RUO - Research Use Only |
