Product Details
| Alternative Name: | Leukotriene B4 Receptor 1, LTB4-R1 |
| |
| Host: | Rabbit |
| |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of rat LTB4 Receptor (BLT1). |
| |
| UniProt ID: | Q9R0Q2 |
| |
| Species reactivity: | Rat
|
| |
| Crossreactivity: | Predicted species reactivity based on epitope sequence homology: mouse. |
| |
| Applications: | WB
|
| |
| Application Notes: | Predicted MW of ~38kDa. Higher MW species (~50kDa) also observed by Western blot which reflect post-translational modification of the receptor. |
| |
| Purity Detail: | Peptide affinity purified. |
| |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.01% sodium azide. |
| |
| Handling: | Keep on ice at all times. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Scientific Background: | Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). LTB4 is a dihydroxy-leukotriene produced in a variety of cells including eosinophils, neutrophils, platelets, and vascular cells, and is a potent leukocyte chemoattractant known to regulate leukocyte activation, cytokine secretion, inflammatory gene transcription, and IgE synthesis. As such, LTB4 has been implicated in a number of disease pathologies including atherosclerosis, asthma, psoriasis, and inflammatory bowel disease. The many actions of LTB4 are associated with two identified mammalian receptors, BLT1 and BLT2. BLT1 is a high-affinity LTB4 receptor expressed on peripheral leukocytes, while BLT2 is a more ubiquitously expressed low affinity LTB4 receptor whose function is not well understood. The BLT1 receptor is transiently expressed by antigen-primed T-cells in humans, and its expression is known to play a critical role in collagen-induced arthritis in mice. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
| Manufacturer: | Manufactured by Proteimax. |
| |
Western blot analysis: MW marker (1) and 50µg rat heart membrane extract (2) probed with LTB4 Receptor (BLT1) pAb at 4.9µg/ml.
Please mouse over
Product Literature References
Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One
12, e0187306 (2017),
Abstract;
Full Text
Related Products
