Product Details
Alternative Name: | BCL2/adenovirus E1B 19kDa interacting protein 3-like, NIX |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to aa 77-92 of human Bnip3L. |
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UniProt ID: | O60238 |
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Species reactivity: | Human
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Applications: | IHC, WB
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Recommended Dilutions/Conditions: | Immunohistochemistry (2µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~40kDa by Western blot. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. In particular, Bnip3L interacts with and overcomes the suppression of apoptosis mediated by Bcl-2 and Bcl-xL. |
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Regulatory Status: | RUO - Research Use Only |
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Immunohistochemistry analysis of human kidney tissue using Bnip3L antibody at 2µg/ml.
Western blot analysis of Bnip3L in K562 whole cell lysate in the absence (A), or presence (B) of immunogenic peptide with Bnip3L antibody (IN) at 1µg/ml.
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Product Literature References
BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation: L.A. Brennan, et al.; Exp. Eye Res.
174, 173 (2018),
Abstract;
General Literature References
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy: J. Zhang & P.A. Ney; Cell Death Diff.
16, 939 (2009),
Abstract;
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