NEDD8
NEDD8 is a small ubiquitin-like protein that can be conjugated to substrate-proteins in a process known as NEDDylation.
Although NEDDylation plays a critical regulatory role in cell growth, viability, and development, the spectrum of NEDD8 substrates and its interaction network remains the subject of much investigation. Originally believed to modify only the cullin family members, it is now recognized that a large number of NEDD8 modified and associated proteins are involved in transcription, DNA repair and replication, cell cycle regulation and chromatin organization, and remodeling.