The over 500 proteases that have been identified in the genome comprise a diverse enzyme family critical for many vital processes. Lysosomal proteases (e.g. cathepsins) and the proteasome comprise the degradative pathways for protein turnover, misfolded and damaged proteins, and thus are major contributors to protein homeostasis, i.e. proteostasis. In contrast, precise and limited proteolysis (e.g. MMPs, ADAMs, caspases, DPPIV) are increasingly recognized as an important form of regulation that activates or inactivates many signaling targets including other proteases, growth factors and peptides.
Enzo Life Sciences offers more than 40 unique serine protease related products specifically related to cancer biomarker discovery, with emphasis on key family members identified as markers of early stage ovarian, breast, prostate and lung cancer (see table).
The only commercially available kit for proteasome quantification.
This kit provides the means to quantify 20S proteasome concentrations in biological samples using a sandwich ELISA technique, utilizing two 20S proteasome specific antibodies for capture and detection purposes together with a highly sensitive substrate. Sample 20S proteasome levels are determined by comparison to a 20S proteasome calibration curve produced in parallel.
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Immunoassay Kits |
Library and Small Molecules |
CELLESTIAL™ Live Cell Analysis Kits |
The MMP RED and GREEN Drug Discovery Kits are complete assay systems designed to screen MMP inhibitors, using long-wavelength quenched fluorogenic substrates. The assays are performed in a convenient 96-well microplate format, with the compound NNGH [1] also included as a prototypic control inhibitor.
