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AMPIPROBE® Nucleic Acid Detection

A Low-Cost Alternative For Nucleic Acid Detection

AMPIPROBE

A Low-Cost Alternative
For Nucleic Acid Detection


Enzo’s mission is to provide low-cost alternative solutions to the diagnostic market. Our AMPIPROBE® platform uses novel PCR design to enable the quantification of nucleic acids for clinically relevant targets. Incorporating our IP into the AMPIPROBE® assays allows Enzo to offer a low-cost option for nucleic acid detection in a price sensitive market.

AMPIPROBE® assays are easily adaptable for laboratory use and cost-effective, without compromising on quality and performance. Compatible on open PCR platforms, AMPIPROBE® assays can be validated on existing instrumentation, eliminating the need for capital expenditures.







Enzo's AMPIPROBE® Technology


AMPIPROBE® is a proprietary technology that incorporates probe detection in primer design. It employs a combination of fluorescent reporter-labeled primers and quencher-labeled primers to amplify DNA, akin to traditional qPCR.

When free in solution, fluorescent primers generate a signal. However, as the primers are incorporated into amplified DNA, the quencher and the fluorophore are brought within close proximity and exhibit Forster resonance energy transfer (FRET). This causes a logarithmic decay of signal with respect to the number of amplification cycles of DNA.

Once the signal decays to a defined threshold, a value is generated with respect to the corresponding cycle. The threshold cycle is indicative of the amount of target RNA or DNA in the sample.

The AMPIPROBE® HCV assay kit is Enzo’s landmark AMPIPROBE® assay for the quantitation of HCV viral load. It has been validated and approved by the New York State Department of Health to be used as a laboratory developed test to quantitatively measure HCV viral load.



AMPIPROBE Quenching
AMPIPROBE Technology

COVID-19 Molecular Testing
AMPIPROBE® SARS-CoV-2 Test System



AMPIPROBE® SARS-CoV-2 Test System on the GENFLEX™ platform




Our AMPIPROBE® SARS-CoV-2 Test System is a complete workflow designed for the qualitative detection of nucleic acids from SARS-CoV-2 virus. It has been authorized by FDA under an Emergency Use Authorization (EUA).

Components:

  1. AMPICOLLECT™ for sample collection*
  2. AMPIXTRACT™ SARS-CoV-2 Extraction Kit for sample processing - nucleic acid extraction from patient specimens
  3. AMPIPROBE® SARS-CoV-2 Assay Kit and Controls for amplification and detection
  4. GENFLEX™ automated high-throughput platform
* Note: AMPICOLLECT™ sample collection is not required by the FDA but it is manufactured by Enzo to offer a complete integrated solution with EUA authorized products. It is equivalent to sample collection offered by competing brands.

Key features:

  • Accurate
    • Clinical Sensitivity: 98.1%
    • Clinical Specificity: 99.3%
  • Low-cost alternative to competitors’ workflows
  • Flexible solution:
    • AMPIXTRACT™ SARS-CoV-2 Extraction Kit and AMPIPROBE® SARS-CoV-2 Assay kit and Controls can be adapted to any open platforms or to manual settings
    • GENFLEX™ platform is an automated open system afor molecular testing
Disclaimer:
This test has not been FDA cleared or approved;
This test has been authorized by FDA under an EUA for use by authorized laboratories;
This test has been authorized only for the detection of nucleic acid from SARS-CoV-2, not for any other viruses or pathogens;
This test is only authorized for the duration of the declaration that circumstances exist justifying the authorization of emergency use of in vitro diagnostics for detection and/or diagnosis of COVID-19 under Section 564(b)(1) of the Act, 21 U.S.C. § 360bbb-3(b)(1), unless the authorization is terminated or revoked sooner.





AMPIPROBE® HCV Assay Kit


The AMPIPROBE® HCV assay kit is Enzo’s landmark AMPIPROBE® assay for the quantitation of HCV viral load. It has been validated and approved by the New York State Department of Health to be used as a laboratory developed test to quantitatively measure HCV viral load.

Key Benefits:

  • Sensitive quantitation of HCV viral load
    • LOD Serum = 5.5 IU/mL
    • LOD Plasma = 7.9 IU/mL
  • Low-cost alternative to other methods of viral load detection
  • Compatible with most open qPCR platforms
  • Complete set of controls including:
    • High, Medium and Low quantitation controls
    • Internal sample extraction control
    • Negative sample control
  • Smaller sample input allows remaining extracted samples to be used in other tests


Read about the validation of the AMPIPROBE™ HCV assay kit for the New York State Department of Health

Featured Literature

Scientific Posters
AMPIPROBE® A Novel, High-Sensitivity, Quantitative Hepatitis C Virus Assay
Product Flyers
AMPIPROBE® HCV Assay Kit
Brochures
PCR & qPCR Complete PCR Solutions

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