Sphingolipids are a versatile class of membrane lipid. In addition to providing mechanical stability, sphingolipids plays a role in molecular signaling, sorting and cell recognition. Therefore, a block in sphingolipid synthesis can compromise cell growth and survival. Sphingosine metabolites, such as ceramide, sphingosine, and sphingosine-1- phosphate are lipid signaling molecules which are involved in a diverse cellular processes. Sphingosine metabolites are potent mediators of cellular stress pathways, accumulation in cells can trigger growth arrest and cell death.
Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2, leading to the formation of sphingosine-1-phosphate (S1P). Sphingosine-1-phosphate is a potent signaling lipid involved in numerous biological functions including, cellular proliferation, survival, migration, invasion, differentiation, architecture, immune cell trafficking, angiogenesis and vascular integrity. Due to its diverse function, S1P has been implicated in a broad range of diseases, including atherosclerosis, respiratory distress, diabetes, cancer and inflammatory disorders.
An essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease.
Produced in E. coli. Human recombinant saposin C (aa 309-388) is fused at the C-terminus to a His-tag and at the N-terminus to a T-7-tag., ≥95% (SDS-PAGE) | Print as PDF