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IL-6 & TNF-α

Adipocytes and/or adipose tissue release a variety of pro-infl ammatory cytokines and chemokines including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). In the absence of an acute infl ammatory process a substantial amount of interleukin-6 (IL-6) is produced by WAT. IL-6 secretion from visceral adipose tissue is three times stronger than from subcutaneous adipose tissue. Plasma IL-6 levels correlate with obesity and have been thought to be implicated in insulin resistance and its complications. Data from human muscle exercise studies have indicated that IL-6 produced by skeletal muscles might improve insulin sensitivity rather than induce insulin resistance. However, these results are under discussion. As for IL-6, obesity is associated with an overexpression of TNF-α. TNF-α expression in WAT was initially demonstrated in rodents to be markedly increased in obese models, and TNF-α was thought to be a mediator of insulin resistance. However, human studies about the role of TNF-α in insulin resistance yielded controversy results.
 

TNF-α Antibodies

TNF-α (human) monoclonal antibody (TNF-D) 

ELISA, Flow Cytometry, FUNC | Print as PDF
 
ALX-804-199-C100 100 µg 290.00 USD
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TNF-α polyclonal antibody 

ELISA, WB, FUNC | Print as PDF
 
ALX-210-335-C100 100 µg 315.00 USD
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TNF-α Proteins

TNF-α (human), (recombinant) (cell culture grade) 

94948-59-1, Produced in yeast., ≥97% (SDS-PAGE) | Print as PDF
 
ALX-520-002-C010 10 µg 195.00 USD
 
ALX-520-002-C050 50 µg 695.00 USD
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TNF-α (soluble) (human), (recombinant) 

Produced in E. coli. The extracellular domain of human TNF-α (tumor necrosis factor-α) (aa 85-223) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag., ≥95% (SDS-PAGE), ELISA | Print as PDF
 
ALX-522-008-C050 50 µg 348.00 USD
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TNF-α (soluble) (mouse), (recombinant) 

Produced in E. coli. The extracellular domain of mouse TNF-α (tumor necrosis factor-α) (aa 77-235) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag., ≥90% (SDS-PAGE), ELISA | Print as PDF
 
ALX-522-009-C050 50 µg 350.00 USD
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TNF-α (human), (recombinant) 

Produced in E. coli., ≥98% (SDS-PAGE; RP-HPLC), ELISA, WB, in vitro Assay | Print as PDF
 
ADI-908-066-010 10 µg 150.00 USD
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Fc (human):TNF-α (soluble) (human), (recombinant) 

Produced in CHO cells. The extracellular domain of human TNF-α (aa 85-233) is fused at the N-terminus to the Fc portion of human IgG1 and a linker peptide (20 aa)., ≥90% (SDS-PAGE) | Print as PDF
 
ALX-522-087-C010 10 µg 452.00 USD
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TNF-α (human), (recombinant) 

Produced in E. coli as a single, non-glycosylated polypeptide. | Print as PDF
 
BML-SE303-0100 100 µg 436.00 USD
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TNF-α ELISA Kits

TNF-α (human), ELISA kit 

Highly sensitive ELISA for measuring TNF-α, the primary mediator of immune regulation.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-099 96 wells 502.00 USD
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TNF-α (human), ELISA kit 

Highly sensitive ELISA for measuring TNF-α, the primary mediator of immune regulation.
ELISA, Colorimetric detection | Print as PDF
 
ADI-901-099 5x96 wells 2,006.00 USD
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TNF-α (mouse), ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-047 96 wells 502.00 USD
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IL-6 Antibody

IL-6 (mouse) monoclonal antibody (6B4 IGH 54) 

ELISA, FUNC | Print as PDF
 
ALX-804-335-C100 100 µg 260.00 USD
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IL-6 monoclonal antibody (2C9) 

WB | Print as PDF
 
ADI-905-884-100 100 µl 363.00 USD
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IL-6 ELISA Kits

IL-6 (mouse), ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-045 96 wells 477.00 USD
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