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C1q Tumor Necrosis Factor-α-Related Proteins [CTRPs]

A highly conserved family of adiponectin paralogs designated as C1q Tumor Necrosis Factor-α-related Proteins (CTRP; C1QTNF) 1-7 (see below) has been described recently. While the seven members exhibit similar structural properties as adiponectin their expression is not restricted to adipose tissue. Among this family, CTRP1 has been reported to be a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking the binding of the Willebrand factor to collagen.CTRP1 expression is increased in adipose tissues of db/db mice and Zucker diabetic fatty (fa/fa) rats and the protein has been shown to stimulate aldosterone production. CTRP2, the mouse paralog with the highest similarity to adiponectin, enhances glycogen accumulation and fatty acid oxidation and has been shown to induce AMPK phosphorylation. CTRP3 (cartducin; CORS-26; cartonectin) has been identified as a novel growth factor important in regulating both chondrogenesis and cartilage development. The protein has been shown to exert anti-inflammatory properties, to be expressed in murine and human adipocytes and to stimulate secretion of other adipokines such as adiponectin and resistin from murine but not human adipocytes. CTRP5 has been associated with retinal degeneration.

Structure of adiponectin/ACRP30 paralogs CTRPs 1–7. The predicted amino acid sequences of all of the CTRPs share a similar modular organization to adiponectin and consist of four distinct domains; a signal peptide (white), a short variable region (purple), a collagenous domain with various length of Gly-X-Y repeats (grey), and a C-terminal globular domain homologous to complement C1q (green). indicates cysteine residues; cysteine residues in the signal peptides are not shown because they are not part of the mature proteins. Adapted from: A family of Acrp30/adiponectin structural and functional paralogs. G. W. Wong, et al.; PNAS101, 10302 (2004).

CTRP Proteins

CTRP2 (globular domain) (mouse), (recombinant) 

Produced in HEK 293 cells. The globular domain of mouse CTRP2 (C1q tumor necrosis factor-α-related protein 2) (aa 151-294) is fused at the N-terminus to a FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
ALX-201-369-C050 50 µg 736.00 USD
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CTRP Antibodies

CTRP5 (mouse) polyclonal antibody (AT114) 

IP, WB | Print as PDF
ALX-210-936-C100 100 µg 290.00 USD
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CTRP7 monoclonal antibody (Anna-1) 

Purified from concentrated hybridoma tissue culture supernatant., ELISA, IHC (PS), IP, WB | Print as PDF
ALX-804-835-C100 100 µg 250.00 USD
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