Glucagon precursor schematic (GRPP = glicentin-related<br />
GLP (glucagon-like peptide) functions in the regulation of blood glucose through insulin, and plays a role in obesity and diabetes. GLP-1 is an important gastrointestinal peptide hormone or incretin, which is released when we eat, produced by tissue specific post-translational processing from a glucagon precursor, and inactivated by dipeptidylpeptidase DPP-4 enzymes. In response to eating, increased levels of GLP-1 stimulate insulin secretion and inhibit glucagon release leading to lower blood glucose levels.