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Oxidative Stress

Visualize Toxic Events In Vitro


Oxidative stress occurs when there is a disturbance in the balance between the production of reactive oxygen species (ROS) and the cell's antioxidant defenses. Exposure to drugs can induce the formation of excess ROS or lower the antioxidant defense systems of the cell. Direct drug metabolism may cause the formation of ROS or other radical species through the oxidative or reductive metabolism of the drug. Other mechanisms can disrupt essential detoxification enzymes, such as superoxide dismutase and glutathione peroxidase in mitochondria, which become overtaxed in stressing conditions. Excessive oxidant species can cause oxidative damage to mitochondrial DNA and proteins, and membrane lipids, which alter cell structure and function. Oxidative damage also aggravates mitochondrial dysfunction and creates more ROS production leading to aberrant cell bioenergetics and cell death.


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What are the different cytotoxicity assays used for in-vitro toxicology?

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Product Highlight

ROS-ID® Hypoxia/Oxidative stress detection kit


Simultaneously monitor hypoxic status and ROS function

  • Specifically distinguishes hypoxia from oxidative stress in real-time
  • High sensitivity, specificity and accuracy for live cell studies
  • Use with adherent or suspension cell lines
  • Complete set of reagents, including ROS and hypoxia inducer controls

Specific Hypoxia Detection in HeLa cells



Hypoxia was detected in HeLa Cells (red fluorescence) treated with DFO. Oxidative stress was detected as green fluorescence.

Solutions for Oxidative Stress

Cell Counting Kit-8 

Colorimetric kit for simple and accurate cell proliferation and cytotoxicity assays.
Colorimetric detection | Print as PDF
 
ALX-850-039-0100 100 tests 81.00 USD
 
ALX-850-039-KI01 500 tests 195.00 USD
 
ALX-850-039-KI02 5x500 tests 588.00 USD
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Cell Counting Kit-F 

Fluorescence microscopy | Print as PDF
 
ALX-850-245-KI01 500 tests 187.00 USD
 
ALX-850-245-KI02 5x500 tests 683.00 USD
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DNA damage ELISA kit 

Rapid DNA damage ELISA kit for cancer, apoptosis and oxidative stress.
ELISA, Colorimetric detection | Print as PDF
 
ADI-EKS-350 96 wells 804.00 USD
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HO-1 (human), ELISA kit 

Highly sensitive HO-1 ELISA kit enabling detection of HO-1 in cell lysates and tissue extracts in < 2.5 hours.
ELISA, Colorimetric detection | Print as PDF
 
ADI-EKS-800 96 wells 681.00 USD
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NUCLEAR-ID® Blue/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53004-C100 100 µl 273.00 USD
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NUCLEAR-ID® Blue/Red cell viability reagent (GFP-CERTIFIED®) 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53005-C100 100 µl 263.00 USD
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NUCLEAR-ID® Red/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53006-C100 100 µl 268.00 USD
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OXI-TEK TBARS assay kit 

Fluorescent detection | Print as PDF
 
ALX-850-287-KI01 160 tests 698.00 USD
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ROS-ID® NO Detection kit 

Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51013-200 1 Kit 189.00 USD
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ROS-ID® Hypoxia/Oxidative stress detection kit 

Specific detection system for simultaneous analysis of hypoxia and oxidative stress using microscopy and flow cytometry
Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51042-0125 125 tests 115.00 USD
 
ENZ-51042-K500 500 tests 400.00 USD
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ROS-ID® ROS/RNS detection kit 

Monitor  reactive oxygen species and nitrogen species in live cells
Fluorescence microscopy | Print as PDF
 
ENZ-51001-200 1 Kit 304.00 USD
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ROS-ID® Superoxide detection kit 

Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51012 1 Kit 189.00 USD
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ROS-ID® Total ROS detection kit 

Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51011 1 Kit 185.00 USD
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ROS-ID® Total ROS/Superoxide detection kit 

Directly Monitor Global Levels  of Reactive Oxygen Species (ROS), and Specifically Superoxide
Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51010 1 Kit 260.00 USD
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