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Mitochondrial Toxicity

Visualize Toxic Events In Vitro


Mitochondria are remarkable organelles that generate ATP to meet the energy needs of cells. They also take in calcium, an important cell signaling molecule, monitor and maintain conditions in the cell and help regulate apoptosis, cellular metabolism, and proliferation. Mitochondrial toxicity can damage many organs and tissues such as the liver, heart, and muscle. Mitotoxicity has become a significant concern for pharmaceutical industries. It can induce severe and sometimes fatal liver injury that can disrupt clinical trials or lead to post-market drug withdrawal. Evaluations of mitochondrial toxicity usually measure ATP content or mitochondrial membrane potential.


Application Note

Monitor Mitochondrial Membrane Potential in Cancer Cell Lines with a Dual-emission Fluorescent Dye

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Product Highlight

MITO-ID® Membrane Potential Cytotoxicity Kit


A real-time mitochondrial membrane potential assay with superior sensitivity

  • 10x more sensitive than JC-1 with superior aqueous solubility
  • Photostable dual-emission dye
  • Separate MITO-ID® Red/Green assays available for detection of mitochondrial mass
  • Suitable for high-throughput applications

High-throughput Analysis of Mitotoxicity



Mitochondrial membrane potential (MMP) decreases with increasing CCCP concentration as indicated by a decrease in orange fluorescence. MITO-ID® is 10x more sensitive than JC-1.

Solutions for Mitochondrial Toxicity

ApoSENSOR™ Cell viability assay kit 

A simple no-wash, chemiluminescent cell  viability assay
Chemiluminescence | Print as PDF
 
ALX-850-247-KI01 200 tests 265.00 USD
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MITO-ID® Membrane potential cytotoxicity kit  

A Real-time Mitochondrial membrane Potential Assay with Superior Sensitivity
HTS, Microplate | Print as PDF
 
ENZ-51019-KP002 1 Kit 278.00 USD
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MITO-ID® Membrane potential detection kit  

The only assay that monitors energetic status using a simple mix-and-read, no-wash protocol
Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51018-0025 25 tests 177.00 USD
 
ENZ-51018-K100 100 tests 489.00 USD
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NUCLEAR-ID® Blue/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53004-C100 100 µl 273.00 USD
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NUCLEAR-ID® Blue/Red cell viability reagent (GFP-CERTIFIED®) 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53005-C100 100 µl 263.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Red/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53006-C100 100 µl 268.00 USD
Do you need bulk/larger quantities?
 

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