Mitochondria are remarkable organelles that generate ATP to meet the energy needs of cells. They also take in calcium, an important cell signaling molecule, monitor and maintain conditions in the cell and help regulate apoptosis, cellular metabolism, and proliferation. Mitochondrial toxicity can damage many organs and tissues such as the liver, heart, and muscle. Mitotoxicity has become a significant concern for pharmaceutical industries. It can induce severe and sometimes fatal liver injury that can disrupt clinical trials or lead to post-market drug withdrawal. Evaluations of mitochondrial toxicity usually measure ATP content or mitochondrial membrane potential. Application NoteMonitor Mitochondrial Membrane Potential in Cancer Cell Lines with a Dual-emission Fluorescent Dye |
Download Our Predictive Toxicology Brochure 
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A real-time mitochondrial membrane potential assay with superior sensitivity
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High-throughput Analysis of Mitotoxicity
Mitochondrial membrane potential (MMP) decreases with increasing CCCP concentration as indicated by a decrease in orange fluorescence. MITO-ID® is 10x more sensitive than JC-1. |
ApoSENSOR™ Cell viability assay kit |
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| A simple no-wash, chemiluminescent cell viability assay | ||||||
| Chemiluminescence | Print as PDF | ||||||
| ALX-850-247-KI01 | 200 tests | 312.00 USD |  |
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MITO-ID® Membrane potential cytotoxicity kit |
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| A Real-time Mitochondrial membrane Potential Assay with Superior Sensitivity | ||||||
| HTS, Microplate | Print as PDF | ||||||
| ENZ-51019-KP002 | 1 Kit | 321.00 USD | |
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| Do you need bulk/larger quantities? | ||||||
MITO-ID® Membrane potential detection kit |
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| The only assay that monitors energetic status using a simple mix-and-read, no-wash protocol | ||||||
| Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF | ||||||
| ENZ-51018-0025 | 25 tests | 204.00 USD | |
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| ENZ-51018-K100 | 100 tests | 565.00 USD | |
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| Do you need bulk/larger quantities? | ||||||
NUCLEAR-ID® Blue/Green cell viability reagent |
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| Distinguishes between live vs dead cells in a single reagent. | ||||||
| ≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF | ||||||
| ENZ-53004-C100 | 100 µl | 316.00 USD | |
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| Do you need bulk/larger quantities? | ||||||
NUCLEAR-ID® Blue/Red cell viability reagent (GFP-CERTIFIED®) |
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| Distinguishes between live vs dead cells in a single reagent. | ||||||
| ≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF | ||||||
| ENZ-53005-C100 | 100 µl | 304.00 USD | |
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| Do you need bulk/larger quantities? | ||||||
NUCLEAR-ID® Red/Green cell viability reagent |
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| Distinguishes between live vs dead cells in a single reagent | ||||||
| ≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF | ||||||
| ENZ-53006-C100 | 100 µl | 310.00 USD | |
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| Do you need bulk/larger quantities? | ||||||
