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Visualize Toxic Events In Vitro


Cytotoxicity is measured primarily as damage to living cells and initiation of cell death and presents in similar ways across cell types. Hepatocytes are important in predictive toxicity studies due to the metabolic drug activities that make them more susceptible to drug compounds. Cell death can be determined by measuring the leakage of cell components, presenting information about membrane integrity and dying cells' mechanism. Standard measures of cell death include lactate dehydrogenase (LDH), DNA binding dyes, or measuring dead cell-specific protease activity. Cell viability can also be used in tandem with cell death markers, most commonly tested by measuring ATP (a measure of living and competent cells).


Application Note

Three Dimensional Hepatotoxicity Screening using Corning® HepatoCells, the Spheroid Microplate, and the SCREEN-WELL® Hepatotoxicity Library

Download Our Predictive Toxicology Brochure


Product Highlight

LYSO-ID® Red Cytotoxicity Kit


A rapid, quantitative live cell cytotoxicity assay compatible with high-throughput screening (HTS)

  • LYSO-ID dye rapidly partitions into cells and labels acidic organelles.
  • Only commercial assay available that allows for long-term cell monitoring of cytotoxic effects.
  • Multi-well, HTS-compatible assay with rapid 10-15 minute dye incubation.

Monitor Dysfunction of Lysosomal Degradation



Drug-induced lysosome accumulation in U-2 OS cells was evaluated using Verapamil (200 µM) and LYSO-ID® Red dye.

Solutions for Hepatotoxicity

LYSO-ID® Red cytotoxicity kit (GFP-CERTIFIED®) 

A Rapid, Quantitative and HTS‐compatible Live Cell Cytotoxicity Assay 
Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51015-KP002 1 Kit 361.00 USD
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NUCLEAR-ID® Blue/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53004-C100 100 µl 273.00 USD
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NUCLEAR-ID® Blue/Red cell viability reagent (GFP-CERTIFIED®) 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53005-C100 100 µl 263.00 USD
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NUCLEAR-ID® Red/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53006-C100 100 µl 268.00 USD
Do you need bulk/larger quantities?
 

SCREEN-WELL® Hepatotoxicity library 

Essential standards for predictive toxicology screening
HTS | Print as PDF
 
BML-2851-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2851-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

Cytochrome P450 Antibodies and Modulators

Cytochrome P450 1A1 (human) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3125-0025 25 µl 100.00 USD
 
BML-CR3125-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 1A1 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3110-0025 25 µl 100.00 USD
 
BML-CR3110-0100 100 µl 329.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 1A1 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3115-0025 25 µl 100.00 USD
 
BML-CR3115-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 1A2 (human) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3130-0025 25 µl 113.00 USD
 
BML-CR3130-0100 100 µl 422.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 1A2 (rat) polyclonal antibody 

IHC (FS), WB | Print as PDF
 
BML-CR3135-0025 25 µl 100.00 USD
 
BML-CR3135-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2A6 (human) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3260-0025 25 µl 100.00 USD
 
BML-CR3260-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2A6 (human) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3265-0025 25 µl 100.00 USD
 
BML-CR3265-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2B6 (human) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3295-0025 25 µl 100.00 USD
 
BML-CR3295-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2B6 (human) polyclonal antibody 

IF, IHC (PS), WB | Print as PDF
 
BML-CR3296-0400 400 µl 506.00 USD
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Cytochrome P450 2C8, 2C9, 2C19 (human) and 2C12 (rat) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3285-0025 25 µl 100.00 USD
 
BML-CR3285-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2C8, 2C9, 2C19 (human) and 2C12 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3280-0025 25 µl 113.00 USD
 
BML-CR3280-0100 100 µl 363.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2D1 (rat) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3210-0025 25 µl 100.00 USD
 
BML-CR3210-0100 100 µl 363.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2D4 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3240-0025 25 µl 100.00 USD
 
BML-CR3240-0100 100 µl 363.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2D6 (human) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3245-0025 25 µl 100.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 2E1 polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3271-0100 100 µl 387.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 3A1 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3310-0100 100 µl 388.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 3A1 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3315-0025 25 µl 100.00 USD
 
BML-CR3315-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 3A4 polyclonal antibody 

WB | Print as PDF
 
ALX-210-276-R100 100 µl 696.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 3A5 (human) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3350-0025 25 µl 100.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 4A1, 4A2, 4A3 (rat) polyclonal antibody 

IHC (FS), IHC (PS), WB | Print as PDF
 
BML-CR3410-0025 25 µl 100.00 USD
 
BML-CR3410-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 4A1, 4A2, 4A3 (rat) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-CR3415-0025 25 µl 100.00 USD
 
BML-CR3415-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 4A1, 4A2, 4A3 (rat) polyclonal antibody 

IHC (FS), WB | Print as PDF
 
BML-CR3420-0025 25 µl 100.00 USD
 
BML-CR3420-0100 100 µl 320.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 polyclonal antibody 

Purified from rabbit serum., WB | Print as PDF
 
ADI-MFO-100-D 50 µg 173.00 USD
 
ADI-MFO-100-F 200 µg 369.00 USD
Do you need bulk/larger quantities?
 

Cytochrome P450 Reductase polyclonal antibody 

Purified from rabbit serum., ICC, IP, WB, Inhibition assay | Print as PDF
 
ADI-OSA-300-D 50 µg 204.00 USD
 
ADI-OSA-300-F 200 µg 443.00 USD
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3-Cyano-7-ethoxycoumarin 

Fluorescent substrate for Cytochrome P450
117620-77-6, ≥98% (TLC) | Print as PDF
 
ENZ-CHM264-0010 10 mg 100.00 USD
 
ENZ-CHM264-0050 50 mg 425.00 USD
 

1-Aminobenzotriazole 

Cytochrome P450 inhibitor
1614-12-6, ≥99% (GC) | Print as PDF
 
BML-EI259-0100 100 mg 143.00 USD
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Benzylimidazole 

Inducer of cytochrome P450
4238-71-5, ≥97% (GC, Titration) | Print as PDF
 
BML-EI162-0005 5 g Inquire for pricing
 
BML-EI162-0001 1 g Inquire for pricing
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3,3’-Diindolylmethane 

Cytochrome P450 activator
1968-05-4, ≥98% (HPLC) | Print as PDF
 
ALX-350-370-M500 500 mg 67.00 USD
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7-Ethoxyresorufin 

Cytochrome P450 substrate
5725-91-7, ≥98% | Print as PDF
 
BML-EI262-0010 10 mg 228.00 USD
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HET-0016 

Cytochrome P450 inhibitor
339068-25-6, ≥98% (HPLC) | Print as PDF
 
BML-EI350-0005 5 mg 99.00 USD
 
BML-EI350-0025 25 mg 389.00 USD
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Itraconazole 

CYP 14-α demethylase inhibitor. Autophagy inducer.
84625-61-6, ≥98% (HPLC) | Print as PDF
 
ENZ-CHM265-0050 50 mg 60.00 USD
 
ENZ-CHM265-0250 250 mg 225.00 USD
 

Ketoconazole 

Cytochrome P450 inhibitor
65277-42-1, ≥99% (HPLC) | Print as PDF
 
BML-EI107-0050 50 mg 61.00 USD
 
BML-EI107-0500 500 mg 297.00 USD
Do you need bulk/larger quantities?
 

Methoxsalen 

Cytochrome P450 inhibitor
298-81-7, ≥98% (GC) | Print as PDF
 
BML-EI132-0001 1 g 58.00 USD
Do you need bulk/larger quantities?
 

Metyrapone 

Cytochrome P450 inhibitor
54-36-4, ≥99% | Print as PDF
 
BML-EI256-0200 200 mg 38.00 USD
Do you need bulk/larger quantities?
 

Muscone 

Induces rat liver microsomal cytochrome P-450
541-91-3, ≥99% (TLC) | Print as PDF
 
BML-EI161-0500 500 mg 293.00 USD
Do you need bulk/larger quantities?
 

Omeprazole 

CYP2C19 inhibitor. H+/K+ ATPase inhibitor.
73590-58-6, ≥98% (TLC) | Print as PDF
 
ENZ-CHM267-0050 50 mg 60.00 USD
 
ENZ-CHM267-0500 500 mg 250.00 USD
 

Piperine 

CYP3A4 inhibitor. Natural product.
94-62-2, ≥98% (HPLC) | Print as PDF
 
ENZ-CHM268-0050 50 mg 45.00 USD
 
ENZ-CHM268-0250 250 mg 150.00 USD
 

R-(-)-Glucoraphanin . potassium salt 

Cytochrome P450 modulator
21414-41-5, Isolated from Brassica oleracea var. palmifolia, ≥99% (HPLC) | Print as PDF
 
ALX-350-181-M010 10 mg 297.00 USD
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Ritonavir 

CYP3A4 inhibitor. HIV1/2 protease inhibitor.
155213-67-5, ≥98% (HPLC) | Print as PDF
 
ENZ-CHM266-0010 10 mg 60.00 USD
 
ENZ-CHM266-0050 50 mg 225.00 USD
 

Roquefortine C 

Cytochrome P450 inhibitor
58735-64-1, Isolated from MST-FP1764., ≥95% (HPLC) | Print as PDF
 
ALX-350-342-MC05 0.5 mg 452.00 USD
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SKF-525A . HCl 

Cytochrome P450 inhibitor
62-68-0, ≥95% (TLC) | Print as PDF
 
BML-EI105-0250 250 mg 94.00 USD
 
BML-EI105-1000 1 g 275.00 USD
Do you need bulk/larger quantities?
 

(S)-Mephenytoin 

Cytochrome P450 substrate
70989-04-7, ≥98% (TLC) | Print as PDF
 
BML-J120-0005 5 mg 88.00 USD
 
BML-J120-0025 25 mg 352.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 (human) and CYP2C12 (rat) pAbs (Prod. No. BML-CR3280, BML-CR3285) 

≥95% | Print as PDF
 
BML-CP0281-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 1A1 (human) pAbs (Prod. No. BML-CR3120, BML-CR3125) 

≥95% | Print as PDF
 
BML-CP0121-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 1A1 (rat) pAbs (Prod. No. BML-CR3110, BML-CR3115) 

≥95% | Print as PDF
 
BML-CP0111-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 1A2 (human) pAb (Prod. No. BML-CR3130) 

≥95% | Print as PDF
 
BML-CP0123-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 1A2 (rat) pAb (Prod. No. BML-CR313) 

≥95% | Print as PDF
 
BML-CP0124-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 2D1 (rat) pAb (Prod. No. BML-CR3210) 

≥95% | Print as PDF
 
BML-CP0201-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 2D6 (human) pAb (Prod. No. BML-CR3245) 

≥95% | Print as PDF
 
BML-CP0265-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 2E1 pAbs (Prod. No. BML-CR3271, BML-CR3275) 

≥95% | Print as PDF
 
BML-CP0270-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 3A1 (rat) pAbs (Prod. No. BML-CR3310, BML-CR3315) 

≥95% | Print as PDF
 
BML-CP0331-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 3A4 (human) pAb (Prod. No. BML-CR3340) 

≥95% | Print as PDF
 
BML-CP0334-0100 100 µg 59.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Cytochrome P450 3A5 (human) pAb (Prod. No. BML-CR3350) 

≥95% | Print as PDF
 
BML-CP0335-0100 100 µg 60.00 USD
Do you need bulk/larger quantities?
 

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