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Genotoxicity

Visualize Toxic Events In Vitro


Identifying genotoxic drug compounds during early preclinical studies allows for further lead refinement and lower drug attrition. Mutagenesis, carcinogenesis, and adverse genetic effects, especially those that affect the germline, are routinely tested. Common assays for mutagenicity, both in vitro and in vivo, identify mutagenic hazards and mitigate risk for regulatory approval. Biochemical assays and cell-based tests used to determine genotoxic events include the Ames test, Comet assay, and micronucleus test. Multiple assays methods are used together to build a complete picture of a drug candidate's genotoxic potential.

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Product Highlight

Comet SCGE assay kit


A fast and simple electrophoresis method to detect and quantitate DNA fragmentation in cells associated with DNA damage and apoptosis

  • Comet slides allow direct application of sample without pretreatment
  • Shorter assay time allows for higher throughput sample analysis
  • Hydrophobic barrier allows sample treatment with DNA repair enzymes
  • Unique nucleic acid stain provides improved sensitivity for DNA visualization compared to ethidium bromides

Bright DNA Damage Detection



Positive control with DNA from cells treated with 100mM H2O2 for 20 minutes at 4°C.

Solutions for Genotoxicity

Comet SCGE assay kit 

Fast and simple electrophoresis method to measure DNA fragmentation
Fluorescence microscopy | Print as PDF
 
ADI-900-166 50 tests 310.00 USD
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BIOARRAY™ 5-hmC methylation kit 

Detect 5-hydroxymethylcytosine using a robust glucosylation method
Print as PDF
 
ENZ-45011-0050 50 tests 596.00 USD
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BIOARRAY™ Deoxyoligo B2 

Print as PDF
 
ENZ-42662-30 30 Reactions 87.00 USD
 
ENZ-42662-150 150 Reactions 386.00 USD
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BIOARRAY™ Eukaryotic hybridization controls 

Biotin-labeled transcripts for microarray internal controls
Print as PDF
 
ENZ-42661-30 30 Reactions 349.00 USD
 
ENZ-42661-150 150 Reactions 1,500.00 USD
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BIOARRAY™ Low Input RNA Amplification and Biotin Labeling System 

Lower RNA Input with High Yield – High Quality Biotin-labeling
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ENZ-42422-0010 10 Reactions 819.00 USD
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BIOARRAY™ methylated DNA IP Kit 

Enrich for methylated DNA (100-fold) from sample for complete diverse downstream applications
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ENZ-45012-0010 10 tests 640.00 USD
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BIOARRAY™ Single-round RNA amplification and biotin labeling system 

Improved data quality and analysis results through greater biotin incorporation.
Print as PDF
 
ENZ-42420-10 10 Reactions 870.00 USD
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BIOARRAY™ Single-round RNA amplification and biotin labeling system (100 reaction) 

Improved data quality and analysis results through greater biotin incorporation.
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ENZ-42421-100 100 Reactions 6,703.00 USD
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BIOARRAY™ Terminal labeling kit with biotin-ddUTP for DNA probe array assays 

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ENZ-42630 25 Reactions 476.00 USD
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CYTAG® CGH Labeling kit 

Superior labeling efficiency and better dye incorporation results in less failed runs
CGH | Print as PDF
 
ENZ-42671-K010 2x10 Reactions Inquire for pricing
 
ENZ-42671-K100 2x100 Reactions Inquire for pricing
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CYTAG® SuperCGH Labeling Kit 

Superior labeling efficiency for low input samples, with greater sensitivity and a simpler workflow
CGH | Print as PDF
 
ENZ-GEN120-0100 2x100 Reactions Inquire for pricing
 
ENZ-GEN120-0010 2x10 Reactions Inquire for pricing
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CYTAG® TotalCGH Labeling kit 

Complete kit to digest and label DNA for CGH+SNP arrays
CGH | Print as PDF
 
ENZ-42674-0010 2x10 Reactions Inquire for pricing
 
ENZ-42674-0100 2x100 Reactions Inquire for pricing
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DNA damage ELISA kit 

Rapid DNA damage ELISA kit for cancer, apoptosis and oxidative stress.
ELISA, Colorimetric detection | Print as PDF
 
ADI-EKS-350 96 wells 804.00 USD
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