Apoptosis, or programmed cell death, is naturally occurring and activated by caspases that cleave proteins. Caspases are classified as effector or initiator caspases and can be used to determine apoptosis. Necrosis is an alternative to apoptosis and is not a regulated process. Injury, diseases, or external factors results in premature cell death that triggers necrosis. Apoptosis and necrosis can be differentiated by evaluating caspase 3/7 pathway activation.
GFP-compatible multiplex assay for distinguishing between healthy, early apoptotic, late apoptotic, and necrotic cells
True multiplexing capabilities with GFP and other green fluorescent
Optimized for both fluorescence microscopy and flow cytometry applications
Suitable for death pathway analysis and drug/toxin studies
Dual Detection of Apoptotic and Necrotic Cells
Apoptosis Detection Reagent (Gold) and Necrosis Detection Reagent (Red) specifically detect cell state with clear spectral separation from mitochondria-associated GFP signal (Green).
Solutions for Cell Death, Apoptosis, or Necrosis Toxicity
Multiplex assay that distinguishes between healthy, early apoptotic, late apoptotic and necrotic cells, compatible with GFP and other fluorescent probes (blue or cyan)
Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF