Binding of Melanocyte Stimulating Hormone (MSH) to the melanocortin 1 receptor (MC1R, a GS-protein coupled receptor) on melanocytes triggers pro-differentiation signals mediated by the second messenger cyclic AMP (cAMP). cAMP-mediated signals inhibit UV-induced apoptosis and promote melanin synthesis via transcriptional activation of pigment regulating enzymes such as tyrosinase. Modulation of cAMP levels by pharmacological induction of adenylate cyclases, or inhibition of phosphodiesterases, hold promise as UV-independent mechanisms of increasing natural production of melanin and protection from UV damage to skin.
Enzo Life Sciences offers the most sensitive and complete colorimetric ELISA kits for quantification of intracellular or extracellular cAMP or cGMP in a variety of sample types.
Measure cAMP, a Regulator of Melanin Synthesis
Graph demonstrates the robust and reproducible nature of the competitive cAMP ELISA kit (Prod. #ADI-900-067) showing standard curves from 10 lots manufactured over 6 years
Vitamin C is known to induce collagen synthesis and provide protection against photodamage. It is also an excellent depigmentating agent because it inhibits the action of the enzyme tyrosinase by reducing o–quinones resulting in a decrease in melanin production. Purity: ≥97%
Recent findings suggest that ebselen functions as a depigmenting compound by inhibiting melanin synthesis and melanosome transfer to keratinocytes. Purity: ≥98% (NMR)
This cell permeable vitamin E
derivative decreases postinflammatory hyperpigmentation after injury through anti-inflammatory action. Purity: ≥97%
Catalase fluorometric detection kit |
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| Fluorescent detection, HTS | Print as PDF | ||||||
| ADI-907-027 | 500 tests | 470.00 USD |  |
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PKA kinase activity kit |
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| Non-radioactive protein kinase assay provides rapid and sensitive detection | ||||||
| Colorimetric detection, Activity assay | Print as PDF | ||||||
| ADI-EKS-390A | 96 wells | 665.00 USD | |
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RO-20-1724 |
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| PDE inhibitor | ||||||
| 29925-17-5, ≥99% (TLC) | Print as PDF | ||||||
| BML-EI117-0100 | 100 mg | 153.00 USD | |
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| BML-EI117-1000 | 1 g | 544.00 USD | |
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Rolipram |
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| PDE inhibitor | ||||||
| 61413-54-5, ≥98% (TLC) | Print as PDF | ||||||
| BML-PD175-0010 | 10 mg | 89.00 USD | |
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| BML-PD175-0050 | 50 mg | 384.00 USD | |
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R-(-)-Rolipram |
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| PDE inhibitor | ||||||
| 85416-75-7, ≥98% (HPLC) | Print as PDF | ||||||
| BML-PD177-0005 | 5 mg | 227.00 USD | |
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Zardaverine |
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| PDE inhibitor | ||||||
| 101975-10-4, ≥98% (HPLC) | Print as PDF | ||||||
| BML-PD195-0005 | 5 mg | 114.00 USD | |
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PDE4A (catalytic domain) (human), (recombinant) |
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| Produced in E. coli. Active catalytic domain of phosphodiesterase 4A. | Print as PDF | ||||||
| BML-SE521-0020 | 20 µg | 604.00 USD | |
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PDE4B2 (catalytic domain) (human), (recombinant) |
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| Produced in E. coli. Active catalytic domain of phosphodiesterase 4B2. | Print as PDF | ||||||
| BML-SE522-0020 | 20 µg | 604.00 USD | |
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PDE4D (catalytic domain) (human), (recombinant) |
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| Produced in E. coli. Active catalytic domain of phosphodiesterase 4D. | Print as PDF | ||||||
| BML-SE523-0020 | 20 µg | 604.00 USD | |
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