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The scientific community around the globe is on a mission to find therapeutic treatment for COVID-19 virus. From whatever angle you are going to tackle this challenge, we provide products to support your research in vaccine development, immunotherapy and drug discovery.

COVID-19 and Coronavirus Related Proteins




Coronavirus (COVID-19 S1) antigen (aa 1-674), (recombinant)


The spike protein (S) of SARS-CoV-2 is the most prominent structure on the outside of the viral particles and the most promising target for both vaccination studies and blocking of viral entry. The spike protein is responsible for binding of the ACE2 host receptor and viral entry. Spike protein-ACE2 interaction is thought to occur through key residues in the receptor binding domain (aa ~450-510).




Vaccine Development


Whether you are looking for antigen candidates in host immunity and vaccination efficacy studies, development of virus blocking peptides, study protein-protein interaction, or need positive controls, reliable and robust antigens are key to your research. Enzo offers a wide selection of coronavirus antigens.


Please check out our extended Vaccine Research & Manufacturing portfolio.

Drug Discovery



Drug repurposing can be an important part of any drug discovery program and has led to several blockbuster drugs. High-content screens and high throughput biomarker monitoring have created new opportunities for pursuing new therapeutic applications.



SCREEN-WELL® FDA approved drug library V2


Accelerates drug optimization with a unique collection of compounds of known safety and bioavailability for diverse targets.

  • Contains more than 100 additional compounds compared to our previous FDA approved library versions
  • 100% known bioactivity and greatest degree of drug-likeness available
  • Recently approved FDA compounds are also included
  • We provide detailed information in our comprehensive documentation for each compound
Drug repositioning or repurposing can be an important part of any drug discovery program and has led to several blockbuster drugs (e.g. Viagra and Rogaine). High-content screens, new biomarkers and noninvasive imaging techniques have created new opportunities for pursuing novel indications for approved compounds. Being FDA approved and in use in the clinics, all of the compounds in SCREEN-WELL® FDA v. 2.0 Approved Drug Library have known and well-characterized bioactivity, safety and bioavailability - properties which could dramatically accelerate drug development and optimization. The library also avoids irrelevant compounds found in similar libraries, such as herbicides, insecticides, sunscreen agents, and cytotoxic agents. This set provides one of the richest sources of bioactives and offers the greatest degree of drug-likeness available. Hits from this set will provide a significant head start in any drug optimization program. Many of the compounds included can also be provided as standalone compounds for further testing.





Drug Discovery Assays




ADAM17 fluorometric drug discovery kit

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), also known as TNF-alpha converting enzyme (TACE), plays an important role in shedding of the main SARS-CoV receptor, angiotensin-converting enzyme 2 (ACE2), and regulation of viral entry. Our ADAM17 fluorometric drug discovery kit is supremely suited to analyze pharmacological modulation of ADAM17 enzymatic activity.







Please check out our extended Drug Discovery portfolio.

Cytokine Storm Monitoring


Emerging data suggest that many patients infected with COVID-19 may die due to an excessive response of their immune system, characterized by the abnormal release of circulating cytokines, termed cytokine release syndrome (CRS). CRS plays a major role in the deterioration of COVID-19 patients from pneumonia through acute respiratory distress syndrome (ARDS) cumulating in systemic inflammation and ultimately multi-system organ failure.

This phenomenon of a plethora of cytokines wreaking havoc throughout the body is often vividly referred to as “cytokine storm”.

Many cytokines take part of the cytokine storm in COVID-19 patients including IL-6, IL-1, IL-2, IL-10, TNF-α and IFN-γ, however a crucial role seems to be played by IL-6, whose increased levels in the serum have been correlated with respiratory failure, ARDS, and adverse clinical outcomes.

View the Full Infographic


IL-6 (human) high sensitivity ELISA kit


Interleukin-6 (IL-6) is a key pro-inflammatory cytokine and a plays a crutial role in the COVID-19-related immune response. We offer one of the most sensitive IL-6 (human) ELISA kit on the market. We offer one of the most sensitive IL-6 (human) ELISA kit on the market.
  • Ultrasensitive - Allows you to quantify low interleukin amounts
  • Highly Specific - Negligible reactivity with other family members
  • Strict Quality Control - Ensures reproducible results, lot-after-lot
  • Scientist Trusted – Regularly cited in peer-reviewed publications for over four decades



Standard curve for IL-6 (human) High-Sensitivity ELISA Kit





Complemetary Cytokine ELISA Assays





Cytokine Storm Signaling Pathway Monitoring


Cytokines bind to receptors on target cells and activate a cascade of intercellular signals. The most common of these pathways is the protein kinase transduction cascade. Here we offer a number of targets to monitor the signal cascade at different stages.

IFN-γ
IFN-γ (human), (recombinant)
IFN-γ (human), ELISA kit

IL-1, IL-10 and TNF-α
IL-10 (human), (recombinant)
IL-10 (human), ELISA kit
TNF-α (human), (recombinant)
TNF-α (human), (recombinant) (cell culture grade)
TNF-α (soluble) (human), (recombinant)
TNF-α Recombinant monoclonal antibody (RMTNFA-1)
TNF-α inhibitor

IL-6
IL-6 (human), high sensitivity ELISA kit
IL-6 High Sensitivity Controls
IL-6 (human), (recombinant)
IL-6 monoclonal antibody (2C9)

IL6-R
IL-6 receptor Recombinant monoclonal antibody (rhPM-1) (Human IgG1κ)
IL-6 receptor Recombinant monoclonal antibody (rhPM-1) (Rabbit IgGκ)

Soluble-IL6-R
IL-6 receptor Recombinant monoclonal antibody (rhPM-1) (Human IgG1κ)
IL-6 receptor Recombinant monoclonal antibody (rhPM-1) (Rabbit IgGκ)

JAK
JAK2 (human), (recombinant) (His-tag)TG101348
AG-490TG101348
Baricitinib phosphateTG101348
MomelotinibTG101348
MS-1020TG101348
RuxolitinibTG101348
TG101348

STAT
Stat1 α polyclonal antibody
[pSer727]Stat1 monoclonal antibody (12C5)
[pSer727]Stat1 polyclonal antibody
[pTyr701]Stat1 polyclonal antibody
[pSer727]Stat3 monoclonal antibody (23G5)
[pTyr705]Stat3 polyclonal antibody
Stat3 monoclonal antibody (7G8)
[pTyr695/Tyr699]Stat5 A/B monoclonal antibody (5G4)
Stat5α polyclonal antibody
Galiellalactone
S14-95
STA-21
Stattic
WP1066

Lymphocytes
CD8α Recombinant monoclonal antibody (YTS 105.18) (Rabbit IgGκ)
CD8α Recombinant monoclonal antibody (YTS 105.18) (Rat IgG2aκ)
CD8β Recombinant monoclonal antibody (YTS 156.7.7) (Rat IgG2bκ)
CD8 β Recombinant monoclonal antibody (YTS 156.7.7) (Rabbit IgGκ)

Blood Vessel
VEGF (human), ELISA kit
VEGF monoclonal antibody (6B7)
VEGF monoclonal antibody (NYRhVEGF)
VEGF Recombinant monoclonal antibody (A.4.6.1) (Mouse IgG1κ)
VEGF Recombinant monoclonal antibody (Human IgG1κ)
MCP-1 (rat), ELISA kit
MCP-1 monoclonal antibody (E10052) (biotin conjugate)
IL-8 (human), ELISA kit
IL-8 (human), (recombinant)
IL-8 monoclonal antibody (NYR-HIL8)
IL-6 (human), high sensitivity ELISA kit
IL-6 High Sensitivity Controls
IL-6 (human), (recombinant)
IL-6 receptor Recombinant monoclonal antibody (rhPM-1) (Human IgG1κ)
IL-6 receptor Recombinant monoclonal antibody (rhPM-1) (Rabbit IgGκ)
IL-6 monoclonal antibody (2C9)
E-cadherin (human) monoclonal antibody (SHE78-7)
E-cadherin monoclonal antibody (ECCD-2)

Liver
CRP (human) ELISA kit
C-reactive protein (human), (recombinant)
Fibrinogen (human) ELISA kit
Fibrinogen (human plasma)
Fibrinogen (human) monoclonal antibody (1D6)
Thrombopoietin (human), (recombinant)
Complement component C3 (human) monoclonal antibody (6F6)
Complement component C3 (human) monoclonal antibody (7C10)
Albumin serum (bovine) monoclonal antibody (25G7)

Scale up Production


Efficient large scale production of recombinant proteins requires careful handling during isolation and purification. This will prevent protein aggregation and contamination issues that can arise during processing. We offer a variety of products to ensure an effective biotherapeutic scale up production.



Protein Aggregation Monitoring


Our PROTEOSTAT® Protein Aggregation Assay provides a simple, homogenous assay format for monitoring peptide and protein aggregation in solution. This assay offers you a sub-micromolar range sensitivity and will allow you to detect as little as 1-5% protein aggregate in a concentrated protein solution. The assay is capable of providing quantitative analysis of protein aggregation in a robust and high-throughput fashion (Z’ factor score >0.5).
  • A simple, sensitive, homogenous fluorescent assay
  • Validated for use with microplate or flow cytometry platform
  • Extensively benchmarked with IgG
  • Optimize buffers and excipients for protein formulation
  • Performs with a wide pH and ionic strength range
  • Use with PROTEOSTAT Protein Aggregation Standards for accurate quantification of aggregated protein in solution



Monitor the ability of an excipient to inhibit protein aggregation. Lysozyme was incubated in the presence or absence of N,N’,N’’-triacetyl-chitotriose (inhibitor of lysozyme aggregation). Aggregation was induced and monitored for several weeks at room temperature.




Protein A Contamination Monitoring


The Protein A ELISA kit is a sensitive and reproducible sandwich assay to quantify Protein A residuals in protein preparations. This extensively validated ELISA kit enables you to efficiently detect natural and recombinant Protein A constructs with up to 100% recovery.
  • Detects 1ppm of Protein A residuals in human IgG
  • Recognizes 4 different Protein A variants
  • Useful for contamination analysis and measurement of Protein A variants in monoclonal antibody preparations
  • Produces results in less than 3 hours with low cost per test




Accelerated Protein Stability Assay


The PROTEOSTAT® Thermal Shift Stability Assay is a rapid, simple screening method based on a novel molecular rotor dye which detects protein aggregation. The assay does not require any prior knowledge of protein structure, sequence or ligand binding activity, and is performed on a thermally regulated fluorimeter or RT-PCR instrument.
  • Perform accelerated screening for protein stability as a function of pH, ionic strength, and concentration
  • Screen for ligand binding to proteins of unknown function
  • Screen protein variants to determine their relative stabilities or excipients to determine optimal protein storage conditions
  • Identify protein-protein interaction inhibitors
  • PROTEOSTAT dye is tolerant of detergents and hydrophobic compounds



Carbonic anhydrase I (1 μM) was incubated with 0 to 62.5 mM of TFMSA (trifluoromethane sulfonamide) in 25 mM MES, 50 mM NaCl, pH 6.1. The ProteoStat Thermal Shift Stability Assay demonstrates that ligand binding increases protein thermal stability by an amount proportional to the concentration of the ligand.





Complemetary Products for Scale up Production




We want to do our part to aid in your battle against
this global healthcare crisis by supporting your research
with up to 30% off.

COVID-19 Detection

COVID-19 Molecular Testing
COVID-19 Serological Testing
Products Related To ELISA Assay Development


COVID-19 Characterization

Coronavirus Antibodies
COVID-19 and Coronavirus Related Proteins
Products Related to Coronavirus Biology



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