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New Grp78/BiP ELISA Kit from Enzo Life Sciences, Inc. Quantifies Critical ER Chaperone and Regulator of Unfolded Protein Response

Figure: Grp78/BiP ELISA Kit from Enzo Life Sciences, Inc.

Enzo Life Sciences expands its offering of unique ELISAs for protein homeostasis (proteostasis), neurodegenerative disorders and cancer research with the introduction of a first to market, high-sensitivity Grp78/BiP ELISA Kit.

Grp78/BiP is an endoplasmic reticulum (ER) specific homologue of (Hsp70), serving as a critical stress-sensing chaperone and regulator of the unfolded protein response (UPR). Grp78 functions to help fold misfolded proteins to prevent protein aggregation, and helps regulate protein degradation, synthesis, transportation and oligomerization. The critical role of ER-stress regulating proteins in maintaining proteostasis, inducing macroautophagy, and the expression of Grp78 on the surface of some tumor cells, makes Grp78 and the UPR pathway a potential target for neurodegenerative and cancer therapies.

This quantitative ELISA kit offers sensitivity to enable quantification of both normal and upregulated levels of Grp78/BiP, detecting as little as 8.4 ng/ml of Grp78/BiP in human, mouse and rat cell lysates or serum samples. The assay provides quantitative results with excellent reproducibility between experiments, offering efficiency over Western blotting by requiring less sample input, and analysis of up to 40 duplicate samples in just 2.5 hours.

Like all Enzo Life Sciences ELISA kits, the Grp78/BiP ELISA kit is complete, flexible, and put through rigorous fit-for-purpose validation and stability testing to ensure high precision, accuracy, sensitivity, and specificity. It is supplied with an easy-to-follow protocol, pre-coated microtiter plate and liquid color-coded reagents to save the user time and reduce errors. The 96-well break-apart strip plate design provides throughput flexibility to minimize waste.

The Grp78/BiP ELISA kit is the most recent addition to Enzo’s industry-leading portfolio of products for heat shock protein, oxidative stress, autophagy, and proteostasis research. For more information or to order the Grp78/BiP ELISA Kit or other Enzo Life Sciences products, please visit us at or call us at 1-800-942-0430.

About Enzo Life Sciences

Enzo Life Sciences, Inc. is a wholly owned subsidiary of Enzo Biochem, Inc. headquartered in Farmingdale, New York. The company is focused on providing innovative life science research reagents worldwide based on nearly 40 years of successful experience in building strong international market recognition, implementing outstanding operational capabilities, and establishing a state-of-the-art electronic information and ordering marketplace.

Enzo Life Sciences, Inc. is a recognized leader in labeling and detection technologies across research and diagnostic markets. Our strong portfolio of assay kits, fluorescent dyes, small molecules, antibodies, proteins, peptides, and compound libraries provides life science researchers tools for target identification/validation, drug discovery, high content analysis, gene expression analysis, nucleic acid detection, protein biochemistry and detection, and cellular analysis.

New Product Release
Date: November 19th, 2013

For additional Information, please contact:
Kara Cannon, Global Head of Marketing
1-631-694-7070 x 145

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