Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Using CYTAG® SuperCGH Labeling Kit for the Analysis of FFPE Oncological Samples by CGH

Download this Application Note

Karine Durand1, Rosaria Esposito2, Morgan Mathieu2, Sylvie Bourthoumieu1
1University Hospital of Limoges, France;
2Enzo Life Sciences, Lausen, Switzerland

Featured Product: CYTAG® SuperCGH Labeling Kit


INTRODUCTION

Microarray-based comparative genomic hybridization (array CGH) is a fast genome-wide screening tool for the high resolution detection of chromosomal anomalies in the form of copy number variations (CNVs).

In the oncology field, aCGH represents a valuable prognostic tool. It allows the identification of the genetic alterations characterizing the tumor of a specific patient, giving precious information on its evolution, and facilitating the choice of the best treatment. However, biopsies are usually preserved in a formalin-fixed paraffin-embedded (FFPE) form. Both the quantity and the quality of the DNA extracted from FFPE tissues are variable, making the analysis by CGH of these specimens challenging.

The cytogenetic service at the University Hospital of Limoges carries out hundreds of prenatal, postnatal, and oncological CGH tests per year on a variety of specimens, including amniotic fluid, blood, and FFPE tissues. The objective of this study was to test Enzo’s CYTAG® SuperCGH Labeling Kit with DNA extracted from oncological FFPE tissues, identifying the best labeling protocol to optimize the results

Read More about Genomics

TechNotes

Our bi-weekly TechNotes are an easy way for you to keep in touch with how Enzo Life Sciences is living up to our motto: Scientists Enabling Scientists™. Each TechNote connects recently published research with one or more of the many solutions Enzo provides for scientists across the life sciences, drug development, and clinical research communities.

Molecular Biology TechNotes

Genomics Product Range

Clear Results With Innovative Nucleic Acid Labeling

Genomics

 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2020 Enzo Life Sciences, Inc.,