Replaces Prod. #: BPD-HYB-310-08
Product Specification
| Clone: | 12C3 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Synthetic peptide corresponding to aa 5-16 of human amyloid β-peptide. |
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| UniProt ID: | P05067 |
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| Species reactivity: | Human
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| Applications: | ELISA
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| Purity Detail: | Protein A/G-affinity purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Short Term Storage: | +4°C |
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| Scientific Background: | Beta-amyloid/Abeta is the major protein component of neurofibrillary tangles and senile plaques, major neuropathological hallmarks of Alzheimer's disease (AD). Abeta occurs in two predominant forms with different COOH-termini, Abeta40 and Abeta42. Abeta is generated by proteolytic cleavage of the amyloid precursor protein (APP) at two sites by distinct secretases, the beta-site secretase BACE, and the multi-subunit gamma-secretase composed of presenilin, nicastrin, Aph-1, and Pen-2. |
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