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BMP-4 (human), (recombinant)

ENZ-PRT259-0020 20 µg 1,138.00 USD
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Product Details

Alternative Name:Bone morphogenetic protein 4
MW:Dimer, 13.1/26.2 kDa (116/232 amino acids).
Source:Produced in genetically modified CHO cells.
UniProt ID:P12644
Formulation:Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).
Purity:≥95% (SDS-PAGE)
Endotoxin Content:≤ 1 EU/µg
Reconstitution:Reconstitute in sterile water at 0.1 mg/mL.
Shipping:Ambient Temperature
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution.
Scientific Background:Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic growth factor family (BMP) and functions as a critical component in the culture and differentiation of stem cells. Active BMP-4 forms a homodimer or a heterodimer with related BMPs. BMP-4 is integral for the differentiation of mesoderm and ectoderm from pluripotent stem cells (iPSCs and ESCs) in stem cell cultures. BMP-4 is also used in culturing cardiomyocytes, early hematopoietic cells, hepatocytes, bone, cartilage, adipocytes, and lung cells, as well as inhibiting early neuronal differentiation.
Regulatory Status:RUO - Research Use Only
BMP-4 (human), (recombinant) chart
Figure 1. Human BMP-4 induced alkaline phosphatase activity in ATDC-5 cells.
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BMP-4 (human), (recombinant) chart

Product Literature References

Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders: N. Darbinian, et al.; Int. J. Mol. Sci. 24, 135 (2023), Abstract;

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