| Alternative Name: | Interleukin-15, IL-T |
| |
| MW: | ~12.9kDa |
| |
| Source: | Produced in E. coli. Contains 115 amino acids. |
| |
| UniProt ID: | P40933 |
| |
| Formulation: | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium bicarbonate, pH 8. |
| |
| Purity: | ≥95% (SDS-PAGE) |
| |
| Endotoxin Content: | ≤1 EU/µg protein (LAL test) |
| |
| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -80°C |
| |
| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
| |
| Scientific Background: | Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
