| Alternative Name: | GDF-11, Bone morphogenetic protein 11, BMP-11 |
| |
| MW: | Dimer, ~12.5/24.9 kDa |
| |
| Source: | Produced in E. coli. Contains 109/218 amino acids. |
| |
| UniProt ID: | O95390 |
| |
| Formulation: | Lyophilized from a sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA). |
| |
| Purity: | ≥95% (SDS-PAGE) |
| |
| Endotoxin Content: | ≤1 EU/µg protein (LAL test) |
| |
| Biological Activity: | Alkaline phosphatase activity in ATDC5 cells; ED50 ≤ 100 ng/mL (≥ 1.0 x 104 units/mg). |
| |
| Reconstitution: | Reconstitute in sterile 10mM HCl at 0.1 mg/mL. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -80°C |
| |
| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
| |
| Scientific Background: | Growth differentiation factor 11 (GDF-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
