| Alternative Name: | AR, AREG, CRDGF, Colorectum cell-derived growth factor |
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| MW: | ~10.1 kDa |
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| Source: | Produced in E. coli. Contains 87 amino acids. |
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| UniProt ID: | P15514 |
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| Formulation: | Lyophilized from a sterile (0.2 micron) filtered solution containing 10 mM sodium phosphate, pH 7.5. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | ≤1 EU/µg protein (LAL test) |
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| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
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| Shipping: | Ambient |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Amphiregulin (AR), an autocrine growth factor, is a member of the epidermal growth factor (EGF) family. AR functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR). AR promotes the proliferation of neural stem cells and epithelial cells. AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor. Inflammation, ischemia, and hypoxia lead to an increase in AR levels in the brain. |
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| Regulatory Status: | RUO - Research Use Only |
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