| Alternative Name: | Neurotactin, CX3CL1 |
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| MW: | ~8.6kDa |
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| Source: | Produced in E. coli. A non-glycosylated protein containing 76 amino acids. |
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| UniProt ID: | P78423 |
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| Formulation: | Lyophilized from a sterile filtered solution containing 0.1% TFA. |
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| Purity: | ≥95% (reducing and non-reducing SDS-PAGE) |
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| Endotoxin Content: | ≤1 EU/µg |
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| Biological Activity: | The activity is determined by the dose dependent chemotaxis of human PBMCs and is typically starting between 10-100 ng/mL. |
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| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Fractalkine, also known as CX3CL1, is an atypical chemokine that was the first of a fourth chemokine motif (CX3C). Fractalkine functions as a T cell and monocyte chemoattractant and is produced by non-haemopoietic cells. Fractalkine is made in a soluble and membrane bound form in activated endothelial cells which is thought to promote adhesion of leukocytes. |
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| Regulatory Status: | RUO - Research Use Only |
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