| Alternative Name: | CTGF-L, CCN5, Connective tissue growth factor-like protein, WNT1-inducible-signaling pathway protein 2 |
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| MW: | ~24.4 kDa |
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| Source: | Produced in E. coli. Contains 228 amino acids. |
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| UniProt ID: | O76076 |
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| Formulation: | Lyophilized. Contains 0.1% trifluoroacetic acid. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | ≤1 EU/µg (LAL test) |
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| Reconstitution: | Reconstitute in sterile 10 mM acetic acid at 0.1 mg/mL. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | WNT1-inducible-signaling pathway protein 2 (WISP-2) is a member of the CYR61/CTGF/NOV (CCN) family of regulatory factors. WISP-2 is expressed in ectodermal, mesodermal, and endodermal lineages, including primary osteoblasts, fibroblasts, mesenchymal stem cells, and adipogenic precursor cells. WISP-2 is a canonical WNT ligand that regulates cell proliferation, adhesion, and metastasis. Secreted WISP-2 promotes mesenchymal precursor cell proliferation and maintains them in an undifferentiated state. WISP-2 promotes osteoblast adhesion and inhibits osteocalcin production in bone-forming osteoblasts. |
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| Regulatory Status: | RUO - Research Use Only |
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