| Alternative Name: | Interleukin-1α, Hematopoietin-1, Lymphocyte-activating factor , LAF, Endogenous pyrogen, Leukocyte endogenous mediator, LEM, Mononuclear cell factor, MCF, IL-1F1 |
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| MW: | ~18.0 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | P01583 |
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| Formulation: | Lyophilized from 10mM Sodium Phosphate pH 8.0, containing 50mM NaCl. |
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| Purity: | ≥98% (SDS & HPLC) |
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| Purity Detail: | Sterile filtered through a 0.2 micron filter. |
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| Biological Activity: | Stimulates the proliferation of mouse D10S cells. |
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| Specific Activity: | 1x109 units/mg. Determined by the ability of IL-1α to stimulate the proliferation of mouse D10S cells. The expected ED50 is typically ≤0.001 ng/mL. |
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| Reconstitution: | Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Handling: | Centrifuge vial before opening. Do not vortex. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -20°C to -80°C. Avoid freeze/thaw cycles. |
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| Scientific Background: | Interleukin-1α (IL-1α) is a protein of the interleukin-1 family. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases. |
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| Regulatory Status: | RUO - Research Use Only |
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