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United States 

IL-13 (human), (recombinant)

ENZ-PRT183-0010 10 µg 264.00 USD
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Product Details

Alternative Name:Interleukin-13, NC30
MW:~12.6 kDa
Source:Produced in E. coli.
UniProt ID:P35225
Formulation:Lyophilized from 20mM sodium phosphate, pH 7.0.
Purity:≥98% (SDS & HPLC)
Purity Detail:Sterile filtered through a 0.2 micron filter.
Endotoxin Content:Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Biological Activity:Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Shipping:Ambient Temperature
Short Term Storage:-20°C
Long Term Storage:-20°C
Scientific Background:IL-13 (interleukin-13) is primarily produced by activated T cells and has many of the same biological properties as IL-4. IL-13 suppresses the expression of pro-inflammatory cytokines such as IL-1, IL-6, TNF-α and IL-8 by monocytes/macrophages, induces CD23 expression on B cells, promotes B cell proliferation, stimulates secretion of IgE and IgG4, and induces IFN-γ production by NK cells. IL-13 has been shown to inhibit the replication of HIV both in vitro and in vivo. IL-13 induces many phenotypes of allergic lung diseases, including airway hyper responsiveness, goblet cell metaplasia and mucus hypersecretion that contribute to airway obstruction.
Regulatory Status:RUO - Research Use Only

Product Literature References

Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease: J. Ousingsawat, et al.; Int. J. Mol. Sci. 23, 1085 (2022), Abstract;
Expression of SLC26A9 in Airways and Its Potential Role in Asthma: J. Ousingsawat, et al.; Int. J. Mol. Sci. 23, 2998 (2022), Abstract;
Pro-Inflammatory Activation of A New Immortalized Human Microglia Cell Line: M. Chiavari, et al.; Brain Sci. 9, 111 (2019), Abstract;

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