| Alternative Name: | Interleukin-1β, Catabolin |
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| MW: | ~17.5 kDa |
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| Source: | Produced in E.coli. |
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| UniProt ID: | P10749 |
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| Formulation: | Lyophilized from 10 mM sodium citrate, pH 4.0. |
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| Purity: | ≥98% (SDS-PAGE gel & HPLC) |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | IL-1β is produced by activated macrophages as a proprotein and cleaved by caspase-1. IL-1β is an important mediator of the inflammatory response, and is involved in a variety of cellular activities including: cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by IL-1β in the CNS is found to contribute to inflammatory pain hypersensitivity. |
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| Regulatory Status: | RUO - Research Use Only |
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