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NGAL (human), (recombinant)

 
ENZ-PRT113-1000 1 ml 318.00 USD
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Product Details

Alternative Name:Neutrophil gelatinase-associated lipocalin, Lipocalin 2, Siderocalin, Oncogene 24p3
 
Source:Produced in E. coli.
 
UniProt ID:P80188
 
Concentration:1000pg/ml
 
Formulation:Liquid. In 0.01 M phosphate buffer, pH 7.4, containing 0.14 M NaCl, 0.5% BSA, 0.5% Tween 20, 0.0016% Phenol red, and 0.1% Proclin 950.
 
Applications:ELISA
 
Shipping:Blue Ice Not Frozen
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
Scientific Background:Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophil lipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilic molecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single protein chain monomers, which form dimers and small amounts of higher oligomers, as well as complexes with matrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by acute kidney injury.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

The Monomer is the Major Form of NGAL in Urine and Plasma in Severe Sepsis: Bangert, et al.; J. Am. Soc. Nephrol. 24, 368A (2013),

General Literature References

Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases: Nielsen, et al.; Gut 38, 414 (1996),
Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase: Kjeldsen, et al.; J. Biol. Chem. 268, 10425 (1993),

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