- Lyophilized set of controls
- Includes high, medium, and low controls
This product is a set of quantitative controls for the determination of IL-6 concentration in biological matrices, such as serum and plasma. The concentrations have been determined using the Enzo Life Sciences IL-6 (human) high sensitivity ELISA kit (ENZ-KIT178). The controls were lyophilized in porcine serum and contain human IL-6 at a low, medium and high concentration.
Product Details
| Alternative Name: | Interleukin-6 |
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| Applications: | ELISA
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| Contents: | 1 high, 1 medium, and 1 low control |
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| Formulation: | Lyophilized in porcine serum. |
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| Reconstitution: | Each control should be reconstituted in 0.5 mL deionized or distilled water. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine, involved in the induction, growth, and differentiation of cells in the immune and hematopoietic systems, and initiates and coordinates inflammatory reaction. Formerly known as B-cell differentiation factor, IL-6 is a 24 kDa protein that is 212 amino acids in length. It is produced by various types of cells, such as macrophages, T-cells, B-cells and fibroblasts. IL-6 is one of the essential factors for antibody production in B cells, a potent growth factor for myeloma and plasmocytoma cells, and induces acute phase proteins in hepatocytes and promotes expansion of activated T-cells. Levels of IL-6 have been shown to increase in serum as a result of burn trauma and sepsis and also in cerebrospinal fluid with acute viral or bacterial infections of the central nervous system (CNS). Increased levels of IL-6 are observed in several inflammatory diseases, such as rheumatoid arthritis, Castleman’s disease and systemic juvenile idiopathic arthritis as well as playing a critical role in the pathogenesis of autoimmune disease. In addition to all of the functions described above, IL-6 also acts as a myokine, which is a cytokine produced by working muscle during exercise. |
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| UniProt ID: | P05231 |
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| Regulatory Status: | RUO - Research Use Only |
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