The Sclerostin ELISA kit is a colorimetric immunometric enzyme immunoassay kit.
Product Details
Alternative Name:
SOST
Sensitivity:
3.2 pmol/l (0-240 pmol/l)
Assay Time:
O/N plus 1.5 hrs
Applications:
ELISA, Colorimetric detection
Application Notes:
For the quantitative determination of Sclerostin in human serum and plasma.
Wavelength:
450 nm
Species reactivity:
Human
Use/Stability:
All reagents of the kit are stable at 4°C (2-8°C) until the expiry date.
Shipping:
Blue Ice
Long Term Storage:
+4°C
Scientific Background:
Sclerostin is encoded by the SOST gene and serves as a negative regulator of bone formation. Wnt ligands bind to Frizzled (Fz) and LRP5/6 receptors to trigger the canonical Wnt signaling cascade, which has been reported to play an important role in bone development. Sclerostin can bind to LRP5/6 to inhibit the canonical Wnt signaling. Antibodies against Sclerostin can block Sclerostin-mediated Wnt inhibition in cell based assays and increase bone mineral density in animal models. Importantly clinical trial studies demonstrate that antibodies against Sclerostin can also increase human bone mineral density. Consequently, Sclerostin is thought to be a superior therapeutic target for osteoporosis treatment over current implemented methods such as treatment with bisphosphonate derivatives.
