The Big Endothelin-1 ELISA kit is a colorimetric immunometric enzyme immunoassay kit with results in 4.5 hours.
Product Details
| Alternative Name: | Big ET-1 |
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| Sensitivity: | 0.02 pmol/l (0-3 pmol/l) |
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| Assay Time: | 4.5 hours |
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| Applications: | ELISA, Colorimetric detection
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| Application Notes: | For the quantitative determination of human Big ET-1 in serum and plasma. |
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| Wavelength: | 450 nm |
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| Species reactivity: | Human
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| Use/Stability: | All reagents of the kit are stable at 4°C (2-8°C) until the expiry date. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ETA and ETB. Activation of ETA increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ETB receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure. |
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| UniProt ID: | P05305 |
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| Regulatory Status: | RUO - Research Use Only |
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| Compatibility: | This product is compatible with the Absorbance 96 Plate Reader.
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