LH is produced by the gonadotroph cells in the anterior pituitary gland. It is responsible for ovulation in women and controls testosterone synthesis in men. An acute rise of LH, referred to as the “LH surge”, triggers ovulation and development of the corpus luteum in females. After ovulation, LH supports the transient life span of the corpus luteum acting on the luteinized granulosa cells. Cell enlargement and increased progesterone production are involved in the luteinization of the granulosa cells, which are closely associated with the developing gamete (egg) in the ovary.
Deficiency of Wnt10a causes female infertility via the β-catenin/Cyp19a1 pathway in mice: J.H. Zhang, et al.; Int. J. Med. Sci. 19, 701 (2022), Abstract;
Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model: L.P.M. de la Torre, et al.; J. Chem. Neuroanat. 123, 102120 (2022), Abstract;
Increased testosterone and proinflammatory cytokines in patients with polycystic ovary syndrome correlate with elevated GnRH receptor autoantibody activity assessed by a fluorescence resonance energy transfer-based bioassay: H. Li, et al.; Endocrine 74, 163 (2021), Abstract;
Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats: S. Canpolat, et al.; Psychoneuroendocrinology 136, 105597 (2021), Abstract;
Tri-ortho-cresyl phosphate exposure leads to low egg production and poor eggshell quality via disrupting follicular development and shell gland function in laying hens: J. Li, et al.; Ecotoxicol. Environ. Saf. 225, 112771 (2021), Abstract;
Autoimmune activation of the GnRH receptor induces insulin resistance independent of obesity in a female rat model: H. Li, et al.; Physiol. Rep. 8, e14672 (2020), Abstract; Full Text
Downregulation of testosterone production through luteinizing hormone receptor regulation in male rats exposed to 17α-ethynylestradiol: P.H. Lin, et al.; Sci. Rep. 10, 1576 (2020), Abstract; Full Text
Samul-tang ameliorates oocyte damage due to cyclophosphamide-induced chronic ovarian dysfunction in mice: J. Kim, et al.; Sci. Rep. 10, 21925 (2020), Abstract; Full Text
microRNA expression profiles in the ventral hippocampus during pubertal development and the impact of peri-pubertal binge alcohol exposure: A. Asimes, et al.; Noncoding RNA 5, 21 (2019), Application(s): ELISA using rat plasma, Abstract; Full Text
Binge drinking and intergenerational implications: Parental preconception alcohol impacts offspring development in rats: A. Asimes, et al.; J. Endocr. Soc. 2, 672 (2018), Application(s): ELISA using rat plasma, Abstract; Full Text
Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging: E.N. Wilson, et al.; Physiol. Behav. 189, 64 (2018), Application(s): ELISA using rat plasma, Abstract; Full Text
Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome: Y.H. Lee, et al.; Nutrients 10, 1430 (2018), Application(s): Rat serum analysis, Abstract; Full Text
Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression: Z. Zhu, et al.; Evid. Based Complement. Alternat. Med. 2017, 9057959 (2017), Abstract; Full Text
Restoration of Spermatogenesis Using a New Combined Herbal Formula of Epimedium koreanum Nakai and Angelica gigas Nakai in an Luteinizing Hormone-Releasing Hormone Agonist-Induced Rat Model of Male Infertility: H.J. Park, et al.; World J. Mens Health 35, 170 (2017), Application(s): Rat blood serum, Abstract; Full Text
Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5α-Reductase 2: M. Ha, et al.; Sci. Total Environ. 563, 566 (2016), Application(s): Serum LH levels were measured, Abstract;
