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Itraconazole

CYP 14-α demethylase inhibitor. Autophagy inducer.
 
ENZ-CHM265-0050 50 mg 60.00 USD
 
ENZ-CHM265-0250 250 mg 225.00 USD
 
Inhibits 14-α demethylase, a cytochrome P-450 enzyme, thus blocking conversion of lanosterol to ergosterol. Itraconazole inhibits glioblastoma cell proliferation in vitro and in vivo, and stimulates autophagic progression through inhibition of cholesterol trafficking from late endosomes and lysosomes to the plasma membrane. Binds Smoothened (SMO) via a mechanism distinct from that of cyclopamine, inhibiting the Hedgehog pathway. Also inhibits angiogenesis via blocking the binding of VEGF to VEGFR2.

Product Details

Alternative Name:Oriconazole, R51211
 
Formula:C35H36Cl2N8O4
 
MW:705.6
 
CAS:84625-61-6
 
Formulation:Lyophilized.
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (1.5 mg/ml, warm).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored unopened at -20°C
 
Regulatory Status:RUO - Research Use Only
 
ENZ-CHM265 structure
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ENZ-CHM265 structure

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