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A1874

Nutlin-based PROTAC targeting on BRD4
 
ENZ-CHM262-0005 5 mg 838.00 USD
 
ENZ-CHM262-0010 10 mg 1,226.00 USD
 
ENZ-CHM262-0025 25 mg 2,514.00 USD
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A1874 is a nutlin-based PROTAC targeting on BRD4, consist of a BRD4-ligand JQ1 linked to a MDM2 E3 ligase ligand RG7388. A1874 possesses dual function as it dose-dependently degraded its target BRD4, accompanied with the downregulation of c-MYC, as well as stabilization of P53 and upregulated P21 due to the efficient engagement of MDM2 by RG7388.

Product Specification

Formula:C58H62Cl3F2N9O7S
 
MW:1173.6
 
CAS:2064292-12-0
 
Purity:≥98%
 
Appearance:White solid.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
ENZ-CHM262 structure
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ENZ-CHM262 structure

General Literature References

MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53: J. Hines, et al.; Cancer Res. 79, 251 (2019), Abstract; Full Text

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