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Optimized and highly cell-permeable chemical degrader of BET bromodomain proteins, based on PROTAC
ENZ-CHM257-0001 1 mg 79.00 USD
ENZ-CHM257-0005 5 mg 174.00 USD
ENZ-CHM257-0010 10 mg 250.00 USD
ENZ-CHM257-0025 25 mg 500.00 USD
ENZ-CHM257-0050 50 mg 894.00 USD
ENZ-CHM257-0100 100 mg 1,562.00 USD
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dBET6 is chemical degrader of BET bromodomain proteins based on PROTAC and led a collapse of global elongation that phenocopies CDK9 inhibition.

Product Details

Appearance:Off-white solid.
Solubility:Soluble in DMSO (240 mg/mL). Insoluble in water.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
ENZ-CHM257 structure
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ENZ-CHM257 structure

General Literature References

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment: G.E. Winter, at al.; Mol. Cell 67, 5 (2017), Abstract; Full Text

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