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dBET6

Optimized and highly cell-permeable chemical degrader of BET bromodomain proteins, based on PROTAC
 
ENZ-CHM257-0001 1 mg 83.00 USD
 
ENZ-CHM257-0005 5 mg 183.00 USD
 
ENZ-CHM257-0010 10 mg 263.00 USD
 
ENZ-CHM257-0025 25 mg 525.00 USD
 
ENZ-CHM257-0050 50 mg 939.00 USD
 
ENZ-CHM257-0100 100 mg 1,640.00 USD
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dBET6 is chemical degrader of BET bromodomain proteins based on PROTAC and led a collapse of global elongation that phenocopies CDK9 inhibition.

Product Details

Formula:C42H45ClN8O7S
 
MW:841.4
 
CAS:1950634-92-0
 
Purity:≥98% (LCMS)
 
Appearance:White to light yellow solid.
 
Solubility:Soluble in DMSO (240 mg/mL). Insoluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
ENZ-CHM257 structure
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ENZ-CHM257 structure

General Literature References

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment: G.E. Winter, at al.; Mol. Cell 67, 5 (2017), Abstract; Full Text

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