TG101348 inhibits JAK2(V617F) with an IC50 of 3 nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2 V617F cells.
Product Specification
| Alternative Name: | Baricitinib phosphate, LY 3009104, SAR302503, N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide |
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| Formula: | C27H36N6O3S |
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| MW: | 524.7 |
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| CAS: | 936091-26-8 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by EM-MS, NMR |
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| Appearance: | Beige powder. |
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| Solubility: | Soluble in DMSO (105mg/ml) or ethanol (21mg/ml). |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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