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United States 


Inhibitor of PDK1, TBK1, IKK-ε, IRF3
ENZ-CHM189-0005 5 mg 83.00 USD
ENZ-CHM189-0010 10 mg 219.00 USD
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BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC50 = 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC50 values ranging from submicromolar amounts (0.368 µM to greater than 450 µM).

Product Details

Alternative Name:N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
Purity:≥97% (HPLC)
Identity:Determined by NMR.
Appearance:White to off-white powder.
Solubility:Soluble in DMSO (80mg/ml).
Shipping:Ambient Temperature
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
ENZ-CHM189 structure
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ENZ-CHM189 structure

Product Literature References

RalA and RalB relocalization to depolarized mitochondria depends on clathrin-mediated endocytosis and facilitates TBK1 activation: S.R. Pollock, et al.; PLoS One 14, e0214764 (2019), Abstract; Full Text