Specific inhibitor for the Chk1/2 kinases with implications for possible treatment of many cancers.
Product Details
| Alternative Name: | 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride |
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| Formula: | C17H19FN4O2S . HCl |
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| MW: | 398.9 |
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| CAS: | 1246094-78-9 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by EM-MS, NMR |
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| Appearance: | White powder. |
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| Solubility: | Soluble in DMSO (73mg/ml) or ethanol (3mg/ml) |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Checkpoint kinases Chk1 and Chk2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. |
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| Regulatory Status: | RUO - Research Use Only |
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