Brivanib inhibits VEGFR -2 with an IC50 of 25 nmol/l and a Ki of 26 nmol/l, VEGFR-1 with an IC50 of 380 nmol/l and VEGFR-3 with an IC50 of 10 nmol/l. It also shows selectivity for FGFR-1 with an IC50 of 148 nmol/l, FGFR-2 with an IC50 of 25nmol/l and FGFR-3 with an IC50 of 68 nmol/l.
Product Specification
| Formula: | C22H24FN5O4 |
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| MW: | 441.5 |
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| CAS: | 649735-63-7 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by EM-MS, NMR |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO (74mg/ml) or ethanol (3mg/ml). |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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