BMS-540215 is an ATP-competitive inhibitor of human VEGFR-2, with an IC50 of 25 nM and Ki of 26 nmol/l. BMS-540215 also showed good selectivity for FGFR-1 (IC50 of 48 nM), FGFR-2 (IC50 of 125 nM), and FGFR-3 (IC50 of 68 nM).
Product Details
| Alternative Name: | BMS-540215, (2R)-1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol |
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| Formula: | C19H19FN4O3 |
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| MW: | 370.4 |
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| CAS: | 649735-46-6 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by EM-MS, NMR |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO (74mg/ml) or ethanol (3mg/ml) |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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