Orally available angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit. Against VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms, it shows IC50 values of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
Product Specification
| Alternative Name: | GW786034 |
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| Formula: | C21H23N7O2S |
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| MW: | 437.5 |
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| CAS: | 444731-52-6 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by EM-MS, NMR |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO (17mg/ml) or ethanol (1mg/ml). |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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