Erlotinib inhibits EGFR tyrosine kinase auto-phosphorylation. Studies in cell lines and enzyme assays have shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl. It has an IC50 of 2 nM against EGFR. It is >1000-fold more sensitive for EGFR than for c-Src or v-Abl.
Product Details
| Alternative Name: | OSI774, CP-358774, NSC718781 |
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| Formula: | C22H23N3O4 . HCl |
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| MW: | 429.9 |
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| CAS: | 183319-69-9 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Off-white to yellow powder. |
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| Solubility: | Soluble in DMSO (3mg/ml) or ethanol (<1mg/ml). |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK: D.R. Mattos, et al.; Mar. Drugs
20, 418 (2022),
Abstract;
Genome-Wide siRNA Screen for Anti-Cancer Drug Resistance in Adherent Cell Lines: E.C. de Bruin, et al.; Bio-Protocol
5, (2015),
Application(s): Cell Culture,
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