Selective for B-Raf against 46 other kinases. SB 590885 dihydrochloride decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E.
Product Details
| Alternative Name: | N,N-dimethyl-2-[4-[(4E)-4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine |
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| Formula: | C27H27N5O2 . HCl |
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| MW: | 539 |
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| CAS: | 405554-55-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow powder solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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