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3'Sulfo Lewis X recombinant monoclonal antibody (E2-B4)

Recombinant monoclonal antibody targeting 3’-Sulfo-Lewis X
ENZ-ABS859-0050 50 µg 566.00 USD
ENZ-ABS859-0100 100 µg 1,049.00 USD
ENZ-ABS859-0500 500 µg 2,655.00 USD
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The anti-3’Sulfo Lewis X is an unconjugated recombinant rabbit monoclonal antibody to 3’sulfo Lewis X. Validated for ELISA, IHC-FR and immunoblotting applications.

Product Details

Alternative Name:3-SLeX
Immunogen:3'Sulfo-Lewis X
Species reactivity:Human
Applications:ELISA, IHC, IHC (FS), IHC (PS), WB
Recommended Dilutions/Conditions:ELISA (20-50 µg/ml)
Immunohistochemistry (paraffin sections 10-40 µg/ml). Antigen retrieval using a TrisEDTA buffer, pH9, is recommended.

Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Purified by Protein A or Protein G affinity chromatography
Endotoxin Content:<0.050 EU/mg as determined by Limulus Amebocyte Lysate (LAL) chromogenic endotoxin assay
Formulation:Liquid. In PBS pH 7.5
Handling:For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Shipping:Ambient Temperature
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:3’-Sulfo-Lewis X is a glycan epitope that has been reported to act as a ligand for the adhesion molecules E- and L-selectin.  The synthesis of 3-SLeX is mediated by the enzyme galactose-3-O-sulfotransferase (GAL3ST2), which is expressed in cell lines with high metastatic potential. Expression of 3-SLeX is therefore potentially relevant to the identification of tumours with poor prognosis and higher likelihood of progression and metastasis.
3-SLeX has been found to be expressed at high levels in the mucins from the lungs of Cystic Fibrosis patients. It has been shown that Pseudomonas Aeruginosa preferentially binds to this form of LeX, and that high levels of expression may be related to more serious infections and chronic colonisation of airway mucins in Cystic Fibrosis.
Regulatory Status:RUO - Research Use Only
3'Sulfo Lewis X recombinant monoclonal antibody (E2-B4) IHC
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3'Sulfo Lewis X recombinant monoclonal antibody (E2-B4) IHC

General Literature References

Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002),
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review), Abstract;

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