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CD57 monoclonal antibody (NK-1)

 
ENZ-ABS852-0100 100 µl 188.00 USD
 
ENZ-ABS852-1000 1 ml 935.00 USD
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Anti-CD57 marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastoma. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5 and CEA.

Product Details

Alternative Name:Human natural killer-1, HNK-1
 
Clone:NK-1
 
Host:Mouse
 
Isotype:IgM
 
Immunogen:Human peripheral blood mononuclear cells.
 
Species reactivity:Human
 
Applications:IHC (PS)
 
Recommended Dilutions/Conditions:Antibody dilutions should be appropriately adjusted and verified according to the detection system used.
Optimal conditions must be determined individually for each application.
 
Application Notes:This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy.
 
Positive Control:Spleen, Tonsil
 
Formulation:This product is supplied as a purified immunoglobulin and contains less than 0.1% sodium azide as a preservative.
 
Shipping:Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:CD57, also known as HNK-1 (human natural killer-1), is a cell surface marker associated with specific immune cell populations. It plays a crucial role in immune response modulation, neurobiology, and various pathological conditions. CD57 is a glycoprotein expressed on the surface of certain immune cells, including natural killer (NK) cells, T cells, and subsets of B cells. In the immune system, CD57 serves as a marker for identifying specific subsets of lymphocytes. Elevated CD57 expression on NK cells, for example, is linked to enhanced cytotoxicity and a more robust immune response against infected or aberrant cells. Additionally, CD57 can be used to distinguish memory T cell subsets, providing insights into the immune system's adaptive memory.
 
Regulatory Status:RUO - Research Use Only
 
CD57 monoclonal antibody (NK-1) IHC
Formalin fixed paraffin embedded human tonsil stained with CD57 antibody.
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CD57 monoclonal antibody (NK-1) IHC

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