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ACTH monoclonal antibody (AH26)

 
ENZ-ABS851-0100 100 µl 188.00 USD
 
ENZ-ABS851-1000 1 ml 1,157.00 USD
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This antibody specifically targets Synacthen (amino acids 1-24 of ACTH) and does not cross-react with CLIP (amino acids 17-39 of ACTH). It effectively stains corticotrophs in the adenohypophysis and proves valuable in the categorization of pituitary adenomas.

Product Details

Alternative Name:Adrenocorticotropic hormone, Corticotropin
 
Clone:AH26
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to amino acids 1-24 from the N-terminal of human ACTH.
 
UniProt ID:P01189
 
Species reactivity:Human
 
Specificity:Specific to Synacthen (aa 1-24 of ACTH).
 
Crossreactivity:Does not cross-react with CLIP (aa 17-39 of ACTH).
 
Applications:IHC (PS)
 
Recommended Dilutions/Conditions:For use with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections. Recommended dilution 1:50-1:200.
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:This product is supplied as a purified immunoglobulin and contains less than 0.1% sodium azide as a preservative.
 
Shipping:Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:ACTH, or adrenocorticotropic hormone, is a a 39 amino acid active peptide hormone produced and secreted by the anterior pituitary gland. It plays a crucial role in the regulation of the adrenal glands and the synthesis of cortisol, a hormone involved in various physiological processes, including the body's response to stress. ACTH stimulates the adrenal cortex to release cortisol into the bloodstream. POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, α-MSH (melanocyte stimulating hormone), β-MSH, γ-MSH, CLIP (corticotropin-like intermediary peptide), lipotropin-β, lipotropin-γ, β-endorphin and Met-enkephalin.
 
Regulatory Status:RUO - Research Use Only
 
ACTH monoclonal antibody (AH26) IHC
Formalin fixed paraffin embedded human pituitary stained with Adrenocorticotropic Hormone antibody.
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ACTH monoclonal antibody (AH26) IHC

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