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Aurora B monoclonal antibody (1521)

 
ENZ-ABS772-0100 100 µg 595.00 USD
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Product Specification

Alternative Name:Aurora 1
 
Clone:1521
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Aurora B (aa 89-251).
 
UniProt ID:Q96GD4
 
Species reactivity:Human
 
Specificity:Recognizes a protein of 39-45kDa, which is identified as Aurora B.
 
Applications:WB
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
 
Regulatory Status:RUO - Research Use Only
 
Aurora B monoclonal antibody (1521) WB
Western blot testing of 1) a partial recombinant protein and 2) human liver lysate with Aurora B antibody.
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Aurora B monoclonal antibody (1521) WB

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